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Is generic duloxetine available to patients with anxiety disorders. This study is not to suggest that use of sulpiride or any antidepressant is beneficial. However, it suggested that these agents are useful for patients with major depressive disorder. In addition to the aforementioned findings regarding antidepressant action in adult subjects, investigators have reported beneficial effects of these agents in adult animal models. For example, administration of imipramine to adult C57BL/6J mice was shown to increase exploratory activity, memory, and activity level, it also decreased immobility during forced swimming activity. Imipramine also enhanced the expression of serotonin 5-HT2A receptor in the prefrontal cortex of these C57BL/6J mice. It is important to note that while imipramine does not appear to cause sedation in this model, it may stimulate the activity of these receptors and induce neuroplastic changes in these models. Imipramine fact appears to increase exploratory behavior in C57BL/6J mice, whereas a dose of placebo did not. Other agents such as ritanserin and venlafaxine appear to decrease depressive-like behavior and antidepressant-like actions in C57BL/6J mice. However, ritanserin has an opposite effect on both these parameters from that of nortriptyline, and there is a lack of data on the effects venlafaxine in these models. Future studies are warranted to establish the relative effects of different agents in these models, as well the pharmacokinetics and pharmacodynamics of different medications in adult mice. In adult rats (8 weeks of age), the antidepressant effect fluoxetine was comparable to that of olanzapine when tested in the passive avoidance paradigm, but fluoxetine was found to be more effective than olanzapine in the forced swimming assay. When administered to adult male Sprague–Dawley rat pups at 8 weeks of age, fluoxetine dose-dependently inhibited activity on the elevated plus maze. However, fluoxetine and nortriptyline were less effective than olanzapine in the non-extinction paradigm, and no difference in the number of successful entries remained observed. Taken together, these results suggest that fluoxetine in rats is more effective than nortriptyline in the administration of an anxiogenic and antidepressant-like agent to adult pups, and that rats were better adapted to antidepressant-induced changes in hippocampal neuroplasticity compared with adolescent pups. There are four studies investigating the effects of imipramine and nortriptyline on the cognitive effects of diazepam in rats, and rats combined with the benzodiazepine. These studies indicated that, when administered as an open-field test, imipramine did not alter the cognitive effects of diazepam in rats, while, when given concurrently with diazepam, imipramine significantly attenuated the acute tolerance to anxiogenic/aversive effects of diazepam. This suggests that there may be some synergists when antidepressants are administered in combination with benzodiazepines. There is some evidence that combined use Duloxetine 4mg $406.22 - $1.13 Per pill of antidepressants and benzodiazepines can produce additive pharmacological effects in rats. This has been considered an additional reason for the discontinuation of a large, long-term, open-label clinical trial of bupropion combined with diazepam in adult rhesus monkeys. It is suggested that any beneficial effects of antidepressants on the behavioral profile of sedative/aversive drugs will be attenuated or blunted by synergistic interaction with benzodiazepines. The use of bupropion in conjunction with diazepam was not found to have an additive or synergistic effect on the administration of two drugs in these animal models. results suggest that at least as an anxiogenic/aversive agent, diazepam may be more effective in combination with bupropion rodent models. Administration of either imipramine or nortriptyline to adult male Sprague–Dawley rats for 4 weeks significantly attenuated the anxiogenic effects of benzodiazepine diazepam as measured by the open field test. However, administration of either imipramine or nortriptyline alone to adult male Sprague–Dawley rats did not attenuate the anxiogenic effects of diazepam. These findings suggest that in the administration of antidepressants and benzodiazepines to healthy adult rats, the acute effects of these drugs on anxiety-like behavior will be attenuated by the synergistic action of a combination the two medications. This information may help to distinguish between the therapeutic potential of combining antidepressants with benzodiazepines in adults and whether the combination should be discontinued in a growing group of patients who have not experienced an improvement in depressive symptoms. addition, further research on the effect of antidepressants pharmacokinetics.

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